Sentence examples for substantially reduced expression from inspiring English sources

In striking contrast, the PKD2-depleted cultures showed substantially reduced expression of all markers mentioned.

For each dCTCF allele tested, the mutant allele substantially reduced expression of the maternally transmitted imprint marker gene.

This SNP substantially reduced expression of type I interferon (IFN) and other proinflammatory mediators and was found almost exclusively in the African-American population.

As indicated in (Figure 1Cv) siRNA directed against HIF-1α substantially reduced expression of ALKBH5 whereas siRNA directed against HIF-2α resulted in a modest, but statistically insignificant increase, of ALKBH5 mRNA.

As a result, the substantially reduced expression of ε-globin gene could also be observed in the K562-SATB1-RNAi K562-SATB1-RNAi K562-SATB1-RNAi-cellsol cells (Fig. 4butC).

Our results indicate that lack of NFAT5 in cells exposed to hypertonicity could lead to different outcomes, with a proportion of the cells dying, probably as result of an enhanced genotoxic stress response, whereas surviving cells did not exhibit conspicuous symptoms of DNA damage but had a substantially reduced expression of cyclins and aurora B kinase.

The effects of Y49 are particularly notable; mutation of this residue abolishes binding and substantially reduces expression in the CGRP receptor (Barwell et al., 2010).

Both 1 and 5 μM of fusion polyamide substantially reduced mRNA expression levels of ERG in LNCaP cells (Fig. 3b).

In contrast, DM + SNE1.0 and DM + vitamin C showed substantially reduced GPx expression relative to that of T2DM.

For both RNPs, depletion of several of the protein components substantially reduced the expression level of the corresponding ncRNA (see Additional file 1).

On the protein level, Sorafenib concentrations ≥10  μM completely abrogated cyclin D1 and substantially reduced the expression of cyclins E1 and A2, respectively.