Pavlovian extinction substantially reduced this effect, with the extinguished reward cue eliciting less reward-seeking than the non-extinguished reward cue.
The curves show a rather long-lasting temperature increase in dead rats and a substantially reduced temperature effect in narcotized rats due to the blood flow and due to the active though still damped thermal regulation [20], [21], [22], [23].
Treatment with ICA and PDTC and Nicotinamide completely reversed the effects of ICA on ICAM-1 mRNA levels and substantially reduced the effects of ICA on TNF- α, IL-2, and IL-6 mRNA levels.
We find VBP15 has novel membrane-stabilizing and immunological properties, and shows potent NF-κB inhibition and substantially reduced hormonal effects.
In one transgenic line, all 2-DE spots identified as omega-5 gliadins were substantially reduced without effects on other proteins.
Whereas overexpression of raaS from two different plasmid systems mimicked the survival-promoting effect of ethambutol, raaS deletion substantially reduced the ethambutol effect on mycobacterial survival.
Use of fractional segment cores substantially reduced the burst effect, yielding linear cumulative drug release versus time plots from days 2 to 14. Thus, a 1/8 fractional segment core gave a 24 h burst of 11.28 mg oxybutynin and, thereafter, zero order release at the target dose of 5 mg/day over 14 days.
For example, inclusion of NO2 in the model substantially reduced the PM10 effect for non-accidental mortality at normal temperature, whereas the inclusion of SO2 had less influence.
Controlling for ANC visits substantially reduced the observed effect of the intervention on perinatal mortality (OR 0.64; 95% CI: 0.52, 0.78) to non-significance (OR 0.81; 95% CI: 0.65, 1.01), when comparing cohorts before and after the MNCH program initiation (Sobel test of mediation P < 0.001).
Implementing a "loop-counting rule," we designed potent anti-HCV shRNAs with substantially reduced off-target effects.
Aconitase is a good marker of oxidative stress caused by superoxide generation because it is not rate-limiting in this pathway and thus its activity can be substantially reduced without major effects on cellular metabolism [27].
