Sentence examples for substantially reduced activity from inspiring English sources

It is a self-administered questionnaire consisting of five items that assess days of missed activity or substantially reduced activity due to headache in three domains schoolwork/paid employment, household work or chores, and non-work (family, social, and leisure) activities.

These results indicate that hSASP28 V187I) has substantially reduced activity at pH6.0 in vitro compared to WT.

We hypothesized that failure to detect the oseltamivir-resistant population by using the NI assay may stem from substantially reduced activity of the R292K variant NA.

Although the Y96L mutant has a substantially reduced activity in steady state assays, the activity does increase with an increasing mutant Cdx concentration, indicating that the role of Tyr96 is primarily in binding and not electron transfer.

Replacing PS with PE (PC:2PE), which is almost completely deprotonated at the pH of this study (pH 7.6) and thus carrying only weak anionic charge, substantially reduced channel activity relative to the reference, but slightly increased activity relative to pure PC membranes.

A recent study showed that a pH below 7.20 substantially reduced rFVIIa activity but that a temperature above 32°C only slightly improved rFVIIa activity [ 197].

Enzyme activity assays show that His90A, Asn155A and His90A-Asn155A mutalls all have substantially reduced MCAT activity, indicating that M. tuberculosis MCAT supports a unique means of proton transfer.

For the JRCSF-N301A mutant, we observed substantially reduced neutralizing activity relative to wild-type virus with all serum samples, indicating that neutralizing activity was at least somewhat dependent on glycosylation at Asn301 (Fig. 6d, left).

The infection with CAST virus substantially reduced MMP2 activity both in Ang II treated young cells and in old untreated cells (Fig. 5C).

Importantly, the Esa1(E338Q) mutant protein has been shown to retain proper protein folding, exhibit substantially reduced HAT activity, and exhibit a dominant negative effect in yeast cells [28].

The allele containing this variant, called ALDH2* 2, is associated with substantially reduced ALDH activity.