Sentence examples for substantially reduced ability from inspiring English sources

We recently defined a mutated variant of the immunodominant domain of Phl p 1, a major grass pollen allergen, with substantially reduced ability to bind Phl p 1-specific IgE [ 9].

More specifically, YU2 trimeric gp120 protein deleted of the third hypervariable (V3) loop had a substantially reduced ability to induce DC migration (mean 64 and 51% of reduction compared to wild-type gp120 at the apical and medial level, respectively).

Employment status was registered prior to and 1 year after OHCA from the Danish Ministry of Employment and Welfare database, using five work categories (WC): WC 1, working full-time and independent of any social welfare; WC 2, unemployed but able to work; WC 3, on sick leave and receiving social welfare; WC 4, substantially reduced ability to work: and WC 5, on early retirement.

It is immediately apparent that the chronic hemolytic variants have substantially reduced abilities to counteract oxidative stresses.

Furthermore, blockade of c-Kit substantially reduced the ability of neutrophils from tumour-bearing mice to generate ROS in 2DG-simulated limited glucose (Fig. 5f, g).

We observed common study design and weaknesses in the methods, which substantially reduced the ability to determine causation and attribution of the interventions.

"These attacks injured and killed civilians receiving treatment in the hospital and medical personnel, significantly damaged the hospital's infrastructure and substantially reduced its ability to treat patients," the report said.

Use of a neutralising antibody to VEGFR2 also substantially reduced the ability of both leptin and VEGF to stimulate tube formation on Matrigel, further confirming the importance of VEGFR2 and its activity as a mediator of leptin's effects on EC differentiation.

Dichotomous coding substantially reduced the ability of the GHQ-12 to distinguish between individuals compared to the four-point coding.

Fatigue was perceived to be an all-pervasive complex experience that substantially reduced the ability to function personally or professionally.

Notably, inhibition of miR-146a expression substantially reduced the ability of NRASQ61K-expressing cells to form colonies in soft-agar and tumors in mice.