This assay could also quantify a patient's response to kinetic stabilizer treatment, which is especially valuable for patients carrying substantially destabilized, rare, or currently uncharacterized TTR mutations.
In its assessment of the building's architectural importance when granting listed status in 2005, English Heritage described it as a "substantially intact and rare survival" with "polite architectural and sculptural features".
Moreover, the estimates of πS and πN were substantially higher when rare variants were included (table 1).
Also, it should be noted that with the decrease in the percentage of causal rare variants/haplotypes, the power for "Rare" and "Both" phenotype models decrease substantially since for these models rare variants/haplotypes are the major carriers of an association signal.
It has been suggested that family samples can provide substantially greater power for rare variant association studies because there is a potential for observing many copies of a rare genetic variant associated with a disease or trait.
Through analysis of simulated data across a wide range of practical scenarios and triglyceride data from the Dallas Heart Study, we show that SKAT can substantially outperform several alternative rare-variant association tests.
And while many areas of science are also getting mapped in different ways, ranging from the universe and other planets to the genomes of living creatures and the properties of elements in the periodic table, graphical depictions of the whole universe of chemically-accessible molecules are rare and substantially incomplete.
Stars brighter and hotter than the Sun are rare, whereas substantially dimmer and cooler stars, known as red dwarfs, make up 85% of the stars in the Milky Way.
EAs are therefore expected to have a substantially higher frequency of rare homozygotes than AAs – 0.006 vs. 0.002, i.e. about three times as many.
While the patients used the verbal descriptors "very common", "common" and "very rare" in ways similar to the European Commission's Guidelines, their usage of the descriptors "uncommon" and "rare" was substantially different from the EU's.
