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Most importantly, blockage of lipid raft organization via the depletion of cholesterol by MCD substantially prevents avicin D-mediated Fas activation and cell apoptosis (Figure 4).
Most importantly, in vivo treatment with IFNγ increases frataxin levels in DRG neurons and substantially prevents DRG neuronal degeneration and neurological dysfunction in FRDA mice.
Oral administration of SCW prior to systemic injection of SCW substantially prevents the joint swelling and destruction typically observed during both acute and chronic phases of the arthritis [ 18].
Overall, our observations are compatible with the hypothesis that a multimodal regimen including a drug, which effectively counters hyperparathyroidism, may prompt a very favourable response in patients with CUA, a hypothesis in line with the recent observation that long-term cinacalcet treatment substantially prevents the occurrence of CUA in dialysis patients [ 7].
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However, existing barriers especially the investment barriers substantially prevent the low carbon technologies and service from being employed effectively.
The introduction of the seven-valent pneumococcal conjugate vaccine (PCV7) has substantially prevented the incidence of pneumococcal invasive diseases caused by vaccine serotypes in developed countries such as the United States, France and Canada [3], [4] with extended benefits to non-immunized individuals by the herd-immunity.
Thus necrosis resulting from energy failure alone was substantially prevented by mtCsA.
All these effects were substantially prevented by glutathione, which effectively removes reactive oxygen species including peroxynitrite (5).
Indeed, the addition of DES substantially prevented damage nearly as efficiently as GSH, although only at 90 min.
Evidence from developed countries shows that mortality from these can be substantially prevented using population-wide and individual-based strategies.
In contrast, a CMV vaccine would not need to have such high efficacy and coverage to substantially prevent CMV transmission.
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