This option could substantially delay or at worst preclude achieving viability for this population (without discontinuation of the program).
There were slight differences between DEFINE and CONFIRM in baseline characteristics, regional enrollment, and rescue criteria, but these differences were not associated with a substantially different treatment effect and did not preclude a pooled analysis.
"If you sell, be sure that you want to be out of the stock because, in order to deduct the capital loss, you're precluded from buying that security, or a substantially identical security, during the period beginning 30 days before the trade date and ending on the 30th day after the trade date," Beckmann says.
Although the low number of hypermethylated genes (>75%) in the paternal pronucleus precludes establishment of statistical significance, their transcriptional noise levels appear substantially lower than those of intermediate-methylated genes.
Although the results of PP2A-C knockdown were not as dramatic as those obtained with SV40ST, probably because the lethality of PP2A knockdown precluded the isolation of pure population of cells with substantially reduced levels of PP2A, the prevention of the FGF-induced p107 dephosphorylation and growth arrest we observed was significant and reproducible in independent experiments.
Measurement of EpCAM expression in MCF7 cells under the same conditions was restricted to a two days time span owing to the substantially bigger size of these cells as compared to HCT8 cells, which precluded further culture under those conditions.
At 34, with 65 caps to his name - a figure likely to be substantially greater were it not for a spree of injuries and a faith that precludes him from playing matches on Sundays - amassed over 10 years, Murray is among the elder statesmen in Vern Cotter's relatively green Six Nations squad.
However, under pathophysiologic conditions, the level of expression of galectin-3 may change substantially so that a low constitutive expression level of galectin-3 does not preclude a prominent function (eg, in liver and heart).
This new system precludes the need for monodisperse aerosol series to simulate polydisperse aerosol data, thus substantially reducing both study length and subject exposure.
For any of the scenarios that fit the observed epidemic, the basic reproduction number, calculated in the presence of the control measures of leuko-depletion and the donor ban, is much lower than this threshold, therefore precluding the potential for a self-sustaining epidemic and limiting the number of future cases substantially.
