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The reviewer determined whether each recording was technically adequate for clinical interpretation, i.e., was not substantially obscured by artifacts that rendered the study uninterpretable for clinical purposes.
Before deconvolution (Fig. 6A), the spines are visible in XY, but substantially obscured by the brighter dendrite in the ZY view.
Moreover, the magnitude of the strain effect in PBMC (FC ≥ 3 for 265 probesets) substantially obscured the gene expression signature of rejection.
In addition, the LD pattern in Africans is sufficiently different from Europeans so that LD relationships in African Americans may be substantially different with a trait-defining variant, thus obscuring the true relationship.
Consistent with the correlation analysis, the DWD method also substantially reduced inter-sample variance, which is likely to obscure differences between the samples.
Moreover, the patterns of reprint orders may be changing substantially over time (for example, an increase in their use as teaching material), which may obscure any potential bias.
Tumors acquire frequent genetic and epigenetic alterations, which can substantially affect gene expression (Raval et al. 2007; Smith et al. 2006) and consequently obscure the association between germline genetic polymorphisms and gene expression (Curtis et al. 2012).
The amount of crosstalk can be substantially reduced by a proper choice of the EEG reference, but it can remain sufficiently large to obscure measurements (Nunez et al. 1997; Sazonov et al. 2007a).
Mr. Mbeki's missteps over the last two years are doubly disquieting because they have obscured an otherwise impressive record of political and economic achievement during the years when he substantially ran South Africa's first multiracial government on Mr. Mandela's behalf.
How obscure?
Not substantially.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com