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The replication of genome-wide pharmacogenomic studies of anti-cancer agents will likely be found to be substantially more problematic than genome-wide studies examining risk of developing a cancer.
Substantially more DPPs through population-wide changes occurred in the most deprived quintile: 2400 (1600-3100) compared with the most affluent quintiles: 1800 (1800–2600).
In the future, we plan to analyze substantially more samples selected from workers with a wide range of benzene exposure to allow us to construct a detailed model of the dose response relationship.
Here, we present a substantially more comprehensive follow-up of the first genome-wide association screen performed in multiple sclerosis (MS), a complex genetic disease with central nervous system inflammation.
Disadvantages of Pdots are that they bleach faster than QDs (but Pdots are substantially more photostable than dyes or fluorescent proteins) and Pdots have wider emission spectra than QDs.
This indicates that over a wide range of characteristics, miRNA hairpins within (related) species are substantially more alike than miRNA hairpin sequences between less-related species.
Fewer secreted hydrolases are predicted in legume endosymbionts than in plant pathogens, but both secrete substantially more solute-binding proteins than are found in the Frankia genomes, suggesting a wider range of nutritional sources used.
DNA transposition-based strategies offer substantially more efficient random strategies and provide means to generate single-copy insertions, thus potentiating the generation of genome-wide insertion libraries applicable in genetic screens.
The increasing evidence for the coast-wide decline in salmon abundance on the Pacific coast of North America [ 49] may have substantially more ecological implications to terrestrial forest food webs than previously recognized [ 5].
"We deserve substantially more.
Many will receive substantially more money.
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