Even though these structures helped to explain various biochemical observations, such as the redundant nature of interactions formed by Arg and Lys residues in the S1 substrate-recognition sub-site, they were substantially different from the more relevant picture represented by the recently described crystal structures of flaviviral NS3Pro in complex with its cofactor NS2B (Fig. 2a and b).
Moreover, Zwickl and Hillis [ 41] demonstrate that increased taxon sampling has a marked effect on reconstruction accuracy so that the phylogeny presented here is expected to be substantially more reliable for the relevant LHC proteins than that of Koziol et al. [ 2].
Finally, this study only addresses 10-year risk for CHD; lifetime CHD risk is substantially greater and may be a more relevant end point for the purposes of targeting therapy (12).
Its retrieval performance is superior to that of Google Scholar, where a search is more time consuming, as substantially more retrievals have to be reviewed to detect one relevant CPG.
Third, while sensor-based approaches for measuring epidemiologically relevant contact networks are objective and substantially more reliable, new sensors need to be developed that overcome the disadvantages of the current generation of sensors.
According to our data, H4K12ac is substantially more accessible for epigenetic alteration than cytosine methylation within developmentally relevant promoters.
For the gaseous pollutant, SO2, this may be a more relevant issue, as SO2concentrations are known to decrease substantially as distance from source increases.
The author found that changes in the translation speed of tropical cyclones over land — which are more relevant to society than those over the ocean — vary substantially by region.
In aqueous media of any relevant pH, aliphatic amines (p Ka ∼ 10 11) are substantially more deactivated by protonation compared to anilines, which possess a lower p Ka.
In this regard, it may be relevant that upper-level students read literature that was substantially more complex and looked closely at more figures during the semester than did the first-year students.
Triazole 3 is also substantially weaker than cADPR, but releases Ca2+ only slightly less potently than the more relevant parent ligand 2, demonstrating that 3 acts as an agonist at intracellular Ca2+ stores (Fig. 4).
