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In this network, N. fowleri and N. gruberi share substantially more gene families than N. fowleri shares with the other species assessed, thus positioning N. fowleri as the closest relative to N. gruberi.
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We show that the data sets contain substantially more gene-wide signals that surpass nominal significance thresholds than expected by chance, and also but less robustly, that there is an overlap in risk between schizophrenia and bipolar disorder.
Indeed, comparing microarray analyses of total and polysome-bound RNAs showed that whereas IR does modify gene transcription, it affects substantially more genes at the level of translation in human astrocytes [60].
Indeed, dominant fish remained closer to the feeding source than subordinate fish (Figure 2A) and were still more active (Figure 2C). Figure 3 shows that, for any given significance threshold, substantially more genes are differentially transcribed between dominant and subordinate Atlantic salmon in the absence (Figure 3A) than in the presence of competitive rainbow trout (Figure 3B).
This is substantially more genes (approximately 2-fold more) than expected on a random basis.
Furthermore, PoA down-regulated substantially more genes than either 20E treatment.
At 72 hpi, substantially more genes were induced in the compatible interaction than in the incompatible interactions.
Furthermore, the two retinoids affected substantially more genes in differentiated keratinocytes (>350) than in proliferating keratinocytes (≈20).
We found that substantially more genes are up-regulated, than down regulated, relative to wild type expression.
The results presented here are both based on more species (five vs. one) and substantially more genes from each species (> 4500 genes per species).
In contrast to the biosynthesis and elongation pathways, substantially more genes in the fatty acid degradation pathway were upregulated, albeit none of them dramatically so (Fig. 3).
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