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In vertebrates, the top bin of non-coding sequences is substantially more conserved than coding in all mammals and chicken (mean Hs-Gg identity 84.63% for non-coding alignments, and 70.76% for coding alignments).
The repertoire of V1R orthologs is substantially more conserved among three ruminant species than between rodent species, raising the possibility that each orthologous ruminant set/pair detects the same or closely related chemical compounds.
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We saved more, studied more, taught more, conserved and appreciated more.
More conserved residues usually have functional importance.
Briefly, highly constrained positions are more conserved.
Are these elements more conserved than enhancers?
Almost all of the cysteine residues are in different positions as well (Cys-102 has only moved to position 100, but most have shifted substantially more), although within the group, most residues are conserved across most sequences.
This revealed that the tail-to-tail organization and alternating pattern of the α and β hemoglobin genes are well conserved in both clusters, as well as that the Atlantic salmon genome houses substantially more hemoglobin genes, including non-Bohr β globin genes, than the genomes of other teleosts that have been sequenced.
However, highly conserved microsatellites (NP3Ms) had a slightly different distribution (table 1), with megabase portions of the human genome containing substantially more of these microsatellites than average, providing clues that at least some microsatellites are not randomly maintained.
Such analysis of the AAA protomers that are best conserved among organisms (AAA2, AAA3, AAA4 and AAA5 in midasin, and AAA1 in dynein) shows that the AAA protomers of midasin and dynein are substantially more closely related to each other than they are to those in the other branches of the AAA family examined (Figs 7, 8).
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