For Sp1 sites of an intermediate quality, intergenic CGIs contain substantially more Sp1 binding sites than CGIs of any other class except for 5' CGIs.
Our free energy calculations agree with this observation, suggesting that for this value of ε binding is very weak: K d = 0.33 M and g cc = − 1.1 k B T. Note that formation of additional bonds in a capsid structure will give rise to substantially more negative binding free energies.
Fewer secreted hydrolases are predicted in legume endosymbionts than in plant pathogens, but both secrete substantially more solute-binding proteins than are found in the Frankia genomes, suggesting a wider range of nutritional sources used.
Obviously, nature is exploiting this property because tyrosine is substantially more frequent within the protein binding sites compared to the frequency of tyrosine generally observed in proteins.
With only tens of amino acids per tail and substantially more interactors, access of cytoplasmic binding partners to the integrin tail must be finely tuned and carefully regulated.
As noted above, the physics-based model sampled with truncation selection for folding and binding is substantially more restrictive in how many non-synonymous substitutions it allows, and the simulated sequences reflect this.
On the contrary, TF binding motifs are substantially more degenerate and therefore likely to be more amenable to nucleotide changes that modulate TF activity to varying degrees.
Evidently, the binding gate is substantially more effective at maintaining processivity under unloaded or hindering-force conditions than under assisting-load conditions.
All the LCOs, except for p-FTAA-Ph, displayed considerably reduced Stokes shifts for Aβ1 42 fibrils compared to ethyl acetate, indicating that the Aβ1 42 binding pocket is substantially more nonpolar than ethyl acetate (ε=6.08).
Again, we observed that dCaP-T2-all is substantially more powerful than MANOVA at all levels of binding strengths.
