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However, substantially lower exposure was reported with 1.9 hours per day in boys and girls aged 15 16 from three regions in Europe [ 22], 1.91 in girls at age 11 in the United States [ 4], and 2.2 in children 11 14 years old in France [ 23].
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In fact, ranibizumab was shown to have a rapid systemic clearance upon egressing into the systemic circulation following ITV administration and substantially lower systemic exposure compared with bevacizumab and aflibercept, which both contain an Fc region.
Metabolite levels predicted from the two models are similar for benzene exposures in the range of 3 100 ppm but differ substantially for lower exposure concentrations.
At substantially lower concentrations of exposure in the more recent 1999 2004 NHANES cohort, we found no evidence of effect modification by sex.
Mortality was substantially lower during current VKA exposure compared to other exposure periods.
Chronic exposure will generally produce adverse health effects at substantially lower doses than acute exposure.
Most recently, a subcutaneous dosing schedule of bortezomib has been developed which appears to be associated with a substantially lower maximum concentration of exposure, with a roughly equivalent area under the curve of exposure and efficacy in patients with multiple myeloma.
The change in the ORs with mutual adjustment did not appear to be an artifact of collinearity because the precision of the mutually adjusted model was not substantially lower than the single exposure model (e.g., CI widths for an IQR change in PM2.5 during pregnancy of 2.3 vs. 1.7, respectively).
The TST reactor proportion for persons with >3 weeks of exposure in the recruit-training platoon was substantially lower than shorter duration of exposure in the rehabilitation and separation units (RR 0.19, 95% CI 0.05 0.66, p = 0.0032).
Steady-state systemic exposures from ITV lampalizumab were substantially lower (11,000-fold) than ocular exposures.
Our results show that silver has the potential to evoke developmental neurotoxicity even more potently than known neurotoxicants, such as CPF, and that the spectrum of effects is likely to be substantially different at lower exposures that do not show signs of outright toxicity.
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