Sentence examples for substantially lower doses from inspiring English sources
Interestingly, Gatenby and collaborators show that this approach, at least in a mouse tumor model, provides better survival than the current standard protocols, notably with substantially lower doses of chemo drugs (Gatenby et al. 2009).
Our study population, comprising critically ill ARDS patients with concomitant organ failure, required substantially lower doses of (approximately) 0.26 µg/kg/min argatroban to achieve the therapeutic aPTT goal.
However, BIND Biosciences has shown a significant reduction of lung and tonsillar lesions using the combination of nanoparticles and chemotherapeutic drug with prostate-specific membrane antigen (PSMA) with greater efficacy compared with the drug alone, and at substantially lower doses.
However, this work proves that a debugged dose response (DR) modeling, through explicit algebraic equations, enables two simple options to accurately calculate the CI of substantially lower doses than NOEC.
Chronic exposure will generally produce adverse health effects at substantially lower doses than acute exposure.
Thus, it was suggested that patients with low TPMT expression should be treated with substantially lower doses of thiopurines.
In natural infections, exposure to CWD agent would likely be sporadic and at a substantially lower dose.
These estimates indicated an increased risk related to substantially lower dose than that suggested by Lamm and colleagues [ 21].
Since glycemic efficacy was similar in the combination group in the context of a substantially lower dose of metformin, linagliptin + LD metformin may be an appropriate treatment alternative, especially in patients who cannot tolerate higher doses of metformin.
77, 78 To address these issues, a procedure was developed that utilized minimally invasive, hydrodynamic occlusion of the liver and allowed for substantially higher levels of hepatocyte transduction with substantially lower viral doses to be utilized.
The impact of these mechanisms is especially important in high-throughput screens such as microfluidic research platforms where the volume of media for each cell is reduced and application of the same concentrations as in bulk experiments may result in a substantially lower cellular dose, which would be more quickly depleted.
