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Younger and less broadly distributed genes are subject to substantially less selective constraint.
Targeting virulence factors for neutralization, rather than targeting organisms for destruction, should exert substantially less selective pressure to drive resistance and is a promising way to approach new therapeutic development for infections [ 13].
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This may be true for highly competitive as well as less selective colleges.
Thus, in all four pairs tested, the isolate with the additional virulence was substantially less competitive, with a selective disadvantage of 17 24%.
Another interesting finding of the present work is that nonmalignant cells (fibroblasts and PBMNC) were substantially less sensitive to RITA than tumor cells, making RITA an interesting tumor-selective drug.
Some students chose more selective schools; some less selective ones.
Now the bank is offering substantially less.
Zhang succeeded partly by making the sieve less selective.
In my experience, the less selective colleges were more welcoming.
If they get substantially less, then the probability declines".
Will there be substantially less money in the system?
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