His later work was less challenging.
And the newsstand is no less challenging.
Furthermore, second half comps are less challenging.
The susceptibility of cattle intracerebrally challenged with the agent of this disease was substantially less than that observed after intracerebral scrapie challenge: nine of nine cattle succumbed to scrapie challenge after intracerebral injection (28).
In challenging economic climates, gross income may well be substantially less than in prior years.
We can guarantee whoever's interested in taking us up on this challenge that they will weigh substantially less and be much stronger than when they started.
Kupffer cell-depleted rats showed substantially less liver damage after partial liver resection, LPS challenge, and alcohol- and acetaminophen-induced liver injury [ 15, 39- 41].
We are currently determining the role that cSPLUNC1 has on the ability of NTHI to colonize the chinchilla nasal cavity as the load of NTHI in this compartment (∼1×104 cfu NTHI per ml NL fluid) is substantially less than that present within the middle ear after direct, transbullar challenge [18].
Identification of patients manifesting ARC remains clinically challenging, principally as many agents (most notably antibacterials) manifest 'silent' pharmacodynamic indices, making under-dosing substantially less visible [ 18].
However, in a time of tightening budgets, the agency's challenge is to build and operate the new telescope for substantially less cost than Hubble.
