It should be noted that under this condition, while most hES cells maintained substantially less cell-cell contact, a certain fraction of the cells occasionally formed small clusters as the local cell density increased (Figure 5A) which differed from the discreetly separated growth of mES cells.
Specifically, when compared to mock-pre-treatment, there was substantially less T cell proliferation on days 3, 4 and 5 in co-cultures with live rHRSV- and IAV-stimulated MDDC and, to a lesser extent, with UV-rHRSV-stimulated MDDC.
In addition, injection of mice with non-mitogenic CD3-antibodies (e.g. CD3-ImmunoglobulinG3) that caused substantially less T cell apoptosis failed to result in a significant increase in systemic TGF-β levels [ 36, 37].
Thus, converging lines of evidence suggest a readout in which opposite cells contribute, but substantially less than congruent cells.
Below their respective CACs, the drugs exist in a classic monomeric form where, at sufficiently high (monomeric) concentrations, they are toxic to cells; however, above their CACs, these drugs form colloidal aggregates that are substantially less cytotoxic in cell assays.
It is evident that splice variants containing deletions in the 5′ VDS are substantially less in somatic cells throughout antrum follicle development than in those cells with this site intact.
As shown in Figure 2A-D, while cell growth was strongly inhibited by anti-estrogen treatment in PTEN-WT cells, growth inhibition was substantially less in PTEN-KD cells.
In particular, we discuss two new insights: degeneracy among CD8 T cells appears to be substantially less than among CD4 T cells, and T cell clones characterized by a high affinity TCR interaction with a given pMHC complex are less degenerate than lower avidity T cells that require higher levels of pMHC complex for their activation.
Normal prostate epithelial cells were substantially less sensitive to AGN194310 than carcinoma cells.
In previous work, we demonstrated that the dose required to kill Jurkat cells is substantially less than that required to kill U937 cells when exposed to 10-ns EP [29], [31].
We conclude that E2-Crimson is substantially less cytotoxic to mammalian cells than other far-red FPs.
