Sentence examples for substantially less activity from inspiring English sources
Sulfur-based analogues do not suffer from toxicity issues, but suffer from substantially less activity and stability than their selenium brethren.
Moreover, the MMP12 promoter construct spanning −32 to +97 showed substantially less activity compared with that spanning −42 to +97 (61.3% vs. 100%, respectively).
This enzyme has substantially less activity with paraoxon (27) and methyl paraoxon (26) with values of kcat/ Km of 1.2 × 10 and 5 × 10 M–1 s–1, respectively.
It is surprising that the mutation of K220 did not completely abrogate activity, but instead resulted in a substantially less active kinase.
The human P347S hammerhead ribozyme was substantially less active (~10,000 fold).
Their monofunctionalized analog and ortho-, meta- or para-heterofunctionalized morpholine-containing complexes with the single carboxyphenylsulfide substituent showed a substantially less inhibitory activity.
Substantially less protective activity was observed in CVL samples obtained from 20 human immunodeficiency virus--infected subjects, but the addition of CVL samples from healthy subjects enhanced the antiviral activity.
We found that IPs of Plk1, Aurora A, and Aurora B from Tim depleted cells had substantially less kinase activity than IPs from siControl treated cells (Fig. 5B).
When caspase-3/-7 activity was assessed, HCA1.7+ also showed substantially less casapse-3/-7 acthanty tHCA1.7−1.7− cells after culture of the cells either in serum-free medium, in 10% FCS or in human serum.
The same households, however, drove substantially less for subsistence activities (e.g., commutes to school and work), which more than compensates for the moderate increase in vehicle miles traveled for household maintenance.
Compared to scrambled control siRNA, SP1 silencing resulted in a robust increase in p120ctn promoter activity in A549 cells, whereas silencing NF-1 had no effect on promoter activity and AP2 silencing resulted in a modest increase in p120ctn promoter activity that was substantially less than that observed for SP1 silencing (Fig. 2).
