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Although effective risk reduction counseling and condom promotion has positive public health implications, substantially larger study sizes may be required to achieve adequate numbers of HIV endpoints in a clinical trial.
Thus, it seems that a substantially larger study would be needed.
However, in order to evaluate clinical endpoints a substantially larger study population and longer observation period are needed.
In the final analysis, this substantially larger study included data from 4506 SNPs typed in 730 multiplex families which between them provided almost 1000 affected relative pairs.
Although we are confident that our analyses are valid within their context, is possible that these factors might be shown to be important in a substantially larger study.
Our study, with substantially larger study samples (n with gout = 24,768 and n with HF = 3,564), was able to detect independent associations with each of these two factors.
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We now propose to conduct a multi-centre study to test these findings in a substantially larger subject group, and to determine the cost effectiveness of this treatment.
A substantially larger recent study of 191 patients with TOF who did not have a chromosomal abnormality or recognised syndrome identified two novel TBX1 variants.
This prospective study is substantially larger than previous studies.
The study was substantially larger than earlier studies, including information from all patients, including those with short survival.
Both studies show an increase of mitochondrial protein abundance in the insect-form cells, however the increase is substantially larger for the study presented here (average of 8.5x) when compared to the study of the monomorphic cells (average of 3.5x).
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