Norway rats reach substantially larger sizes, especially in urban areas [32] than other members of the genus, and are unlikely to be attacked by most house cats [20](Fig 3) compared to smaller congeners such as Rattus rattus, whose adult body size, of approximately 200 g, tends to be that of juvenile R. norvegicus [22], [32].
Improved activity in the combination treatment group was also noted when drug administration occurred when tumours reached a substantially larger size (300 mm; Fig 2B).
The sequencing of the P. pacificus genome revealed many important and unexpected features, such as a substantially larger size and a higher number of predicted protein-coding genes when compared to C. elegans, the presence of horizontal gene transfer and the duplication of genes encoding enzymes involved in the detoxification of xenobiotics [ 25].
While the difference from our findings may reflect the substantially larger size and greater statistical power of the 1958 Cohort, our finding of a null association between socioeconomic position and E-selectin, another key endothelial function marker, supports the validity of our observation.
The SrFe12O19 magnets have fine grain sizes in the cross-plane direction and substantially larger grain sizes in the in-plane direction.
Our results show that i) model selection and parameter estimation improve with larger sample sizes and ii) consistent with previous work [ 19, 20], recent demographic events are more challenging and require substantially larger sample sizes for accurate inference.
Further, since chemisorption uses substantially larger sample sizes (up to 0.25 g) compared to CV (<0.01 g), reliability of chemisorption data is much more reliable and should be considered as the metric for surface Pt site determination.
Thus, substantially larger sample sizes are required for a highly statistically significant estimation of the HF frequency reported in this study (1.46%).
While rigorous statistical methods, such as mixed effects regression or survival analysis techniques, are the preferred method for deriving mean assay window periods (see e.g., [22]), such methods require substantially larger sample sizes than were available for this analysis.
Although effective risk reduction counseling and condom promotion has positive public health implications, substantially larger study sizes may be required to achieve adequate numbers of HIV endpoints in a clinical trial.
RMSE for parameter estimates under models with recent divergence indicated that substantially larger sample sizes were needed for accurate parameter estimation in cases of recent isolation.
