"substantially lack" is correct and usable in written English.
You can use it when referring to something that is missing to a large or significant degree. For example: "The poor family's pantry substantially lacked the necessary supplies to get through the winter."
A comparative analysis to developments abroad can help illustrate the situation better: women are not only compensated unfairly compared to their male counterparts, but they also substantially lack representation and voice.
For dosimetry of Y from post-therapeutic bremsstrahlung, images that substantially lack quality must be quantified.
The importance of FcγRI and FcγRIIb in the synovial inflammation of RA patients is further highlighted by the fact that healthy synovia lack FcγRI expression and substantially lack FcγRIIb expression.
However, our studies demonstrate that sub-clones of GH3/B6 cells that substantially lack the membrane version of ER-α[D9 subline (Pappas et al. 1994)] cannot respond to E2 or XEs via Ca2+ fluxes, PRL release (these studies), or ERK activation (Bulayeva et al. 2004; Bulayeva and Watson 2004).
Policymaking for intermodal and multimodal transport is also substantially lacking.
These segmentation algorithms were only simulated, i.e., the hardware implementation of these algorithms is substantially lacking.
Moreover, most of the case studies were concentrated on the brands having Western-origins, and the cases of Asian apparel brands were substantially lacking in literature.
Nevertheless, tools to accurately assign functional and disease relevance to sequence variants are substantially lacking.
When the Institute of Medicine recently assessed the current state of affairs in U.S. health care, they found it to be substantially lacking in key areas [ 1].
However, data about EGFR gene silencing by promoter methylation are substantially lacking and may help clarifying the role of this epigenetic mechanism on colorectal cancer biology (Scartozzi et al, 2009).
Ultimately, the results indicate that despite almost two decades of research effort, our knowledge of pharmaceutical occurrence and effects in the environment is still substantially lacking when compared to that of other aquatic pollutants.
