Sentence examples for substantially increased activity from inspiring English sources
Replacement of the two overhanging adenosines with pyrimidines substantially increased activity at room temperature by keeping the template overhang out of the active site, confirming the importance of base stacking.
Protein engineering has produced P450 enzymes with widely altered substrate specificities, substantially increased activity and higher stability.
A substantially increased activity of AMPK may play a crucial role.
In summary, the lower expression temperature substantially increased activity of five mutant proteins, further supporting the hypothesis that deficient CBS activity may be in some instances caused by misfolding that may be alleviated by folding permissive conditions.
In both experiments, the immunoisolated membranes had substantially increased activity (about twofold or more than fivefold in the SEC22B or KDELR immunoisolated membranes, respectively) compared to the total input membrane.
In stark contrast, T3 supplemented hypothyroid rats exhibited substantially increased activities of all enzyme complexes in liver SMP.
It has high activity on ampicillin and promiscuous (i.e., low, but nonzero) activity on 'extended-spectrum' cephalosporins cefotaxime (CTX) and ceftazidime (CAZ), but can substantially increase activity on these novel antibiotics through the substitution of a wide range of mutations (Blazquez et al. 2000; Fujii et al. 2004; Salverda et al. 2011; Schenk et al. 2012).
This lack of effect of gefitinib on EGFR activity was not due to receptor dysfunction as EGF challenge substantially increased EGFR activity, together with Akt and ERK1/2 activity indicating that the EGFR signalling pathway was intact.
However, despite low attendance rates, the counselling on physical activity may still have substantially increased physical activity levels.
The screening study disclosed that impregnating activated carbons with platinum substantially increased the activity for SO2 oxidation.
In contrast to the wild-type CBS about half of mutants were not activated by S-adenosylmethionine. Expression at 18°C substantially increased the activity of five mutants in parallel with increasing the amounts of tetramers.
