She said it would be impossible to "substantially raise the standard of care" without a significant increase in Government spending.
If Rakoff's decision is upheld, many settlements might become substantially more difficult or impossible to reach.
This argument renders the origin of metabolism as an RNA-based metabolic reaction system not impossible, but substantially less probable.
Because the evolutionary rate distributions for uORFs in ALT and CONSTIT regions substantially overlap, it is impossible to rule out the possibility that there are small subsets of highly conserved alternative uORFs, a potential target for future investigations.
The rapidly growing sprawl of Phoenix, in the Arizona desert, consumes less than it did a decade ago.So although most observers agree that water-consumption habits in the region must change substantially, that does not look impossible.
As a result, any two performances will have a substantially different form, an effect difficult or impossible to obtain with standard notation.
All of these sources of credit would have been substantially more difficult – and in many cases impossible – to access if our financial system had been allowed to collapse.
"That gives the banks high price-earnings multiples that make it virtually impossible for most insurance companies, with substantially lower price-earnings multiples, to be buyers".
There are many constraints around national standardized tests, college application processes and requirements, etc, that make it almost impossible for you to have a substantially different curriculum.
As the title suggests, it is impossible to hear this track without feeling substantially perked up.
