The normal expression of CIITA, which is selectively up-regulated by IFN-γ, argues that it does not contribute substantially and thus implicates the IFN-α most strongly.
High-grade inflammation together with its impact on traditional risk factors and genetic determinants is strongly implicated in the substantially increased risk of cardiovascular disease (CVD) and mortality experienced by patients with rheumatoid arthritis (RA) [ 1– 4].
Although in the past it was not thought to affect pediatric populations substantially, CDI has more recently been implicated as an increasingly prevalent diarrheal pathogen in children (8 – 10 ).
The above-mentioned investigations on miRNAs implicated in breast cancers substantially advance our knowledge about the roles of specific miRNAs in breast cancer development and metastasis.
Although comprehensive genetic testing, such as WGS, will identify new genes implicated in cardiomyopathy, a substantially higher number of VUS's will also be generated, potentially increasing overall ambiguity.
By screening the JHDL at multiple concentrations, we substantially increased the number of hits implicated, thus, increasing our chances of identifying an optimal drug target for increasing β-cell mass.
Only if Ka/Ks is substantially greater than one is adaptive evolution strongly implicated, although it remains a possible explanation for even small increases in Ka/Ks.
The coerced public confession and reprimand of Jones is a stark contrast to the terse silence and tacit forgiveness of implicated professional baseball players, many of whom are substantially higher-paid athletes.
Specifically, sustained attention and arousal, relying on a prefrontal-parietal network as well as on the basal forebrain and thalamus, are substantially reduced under sleep deprivation and are known to be implicated in memory functions [49] [52].
Bang et al. [ 43] have shown that oxidation of citrullinated vimentin, implicated as an autoantigen in RA, leads to substantially increased antibody reactivity to this antigen in RA.
