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Tangram achieves substantially higher specificity than the two competing algorithms.
Pauleit et al. [ 5] confirmed the lower sensitivity of FET-PET (75% versus 93%) and reported a substantially higher specificity (95% versus 79%) in comparison to FDG-PET.
FET has a lower sensitivity (75% versus 93%) but a substantially higher specificity (95% versus 79%) for detecting tumours compared with FDG.
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Compared to the range of 5 10° in the old KSS [ 15], the range of 2 10° had substantially higher accuracy and specificity in the current study.
The discriminant analysis based on clinical measures was substantially higher, in particular for specificity, which was 100% relative to only 77% for the fMRI based GPC classification, while the sensitivity measures for the ADHD classification were relatively comparable, with 93.3% and 96.3% for the clinical measures, and 90% for the fMRI- based GPC analysis.
All specificity results were comparable to those reported by Goodman and colleagues [ 21], except for conduct disorders, for which specificity was substantially higher than in the British sample.
However, more prolonged delays of ≥18 and ≥24 weeks had substantially reduced sensitivity for LTFU despite higher specificity.
Although consistently abnormal results throughout the acute illness may have been more convincing, the test's specificity (99%) is substantially higher that its sensitivity (66%) (Middleton et al. 2006).
Conversely, a meta-analysis comparing MRI and endoanal US for detection of perianal fistulas concluded that the sensitivity of both methods is similar, although the specificity of MRI is substantially higher [9].
As with CT, the specificity of MR is substantially higher at 94%.
In summary, in this real-life multicentre and multinational study, the 2010 ACR/EULAR classification criteria for RA showed a substantially higher sensitivity than the 1987 criteria, while the specificity was somewhat lower.
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