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Compared with THC, SCs have a substantially higher potency often resulting in exaggerated neuropsychiatric effects.
Once inside the cell, pemetrexed is an excellent substrate for the enzyme folylpolyglutamate synthase (FPGS) [ 20], which rapidly converts pemetrexed to its active polyglutamate derivatives that have a substantially higher potency for inhibition of TS and GARFT [ 21].
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A mixture of equal amounts of two different anti-VLY scFvs showed substantially higher neutralizing potency on the hemolytic activity of VLY as compared to single scFv.
This compound exhibited substantially higher FAAH inhibitory potency (IC50 ≈ 8 μM) than ibuprofen (IC50 ≈ 100 μM), while retaining ibuprofen's COX inhibitory activity.
The opening of the ring at C-7 and C-8 is consistent with the reduction of cytotoxic potency; however, such modulation does not account for the tolerability of substantially higher dose levels than with PTX.
Costs are substantially higher today.
Or a substantially higher fine for littering.
But we see valuations moving substantially higher.
Government publications claimed substantially higher growth rates.
In Texas, the corresponding number was, at 0.5percentt, substantially higher.
Mr. Clover said taxes were substantially higher in coastal towns.
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