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It came to news in recent past that a pharmaceutical company named Starpharma Holdings Ltd has come up with dendrimer-doxorubicin formulation which on intratracheal administration to rats appears to yield substantially higher efficacy in overcoming lung metastases as compared to that of the drug alone [50].
However, a vaccine with substantially higher efficacy (e.g. one with 90% efficacy) could be beneficial and prevent the adverse outcome if the duration of protection is sufficiently long (or if the duration is extended with a boosting programme).
PDT of transplanted syngeneic tumors demonstrated a substantially higher efficacy of 5 compared with chlorin e6 and 2. The boronated compound 5 was capable of penetrating through planar lipid membranes in the ionic form whereas the boron-free 2 was not.
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Firstly, although AS & AQ monthly is the most costly IPTc regimen to deliver (at US$13.16 per child enrolled or US$14.79 per child fully adherent, it is the most cost effective option given its substantially higher protective efficacy.
The overall results showed that their proposed method attained a substantially higher degree of efficacy.
However, the efficacy of each mixture was substantially higher than that of deltamethrin against a multilocus-resistant An. gambiae population of mosquitoes (mainly composed of the molecular S form) carrying 2 resistance genes for pyrethroids and OPs/carbamates (kdr and Ace1 R, respectively), at moderate to high frequency.
However, for sexual transmission to explain the persistence of HCV in Africa before the introduction of medical technologies in the 20th century, one has to postulate a transmission efficacy to HCV-seronegative sexual partners substantially higher than 1% per year, otherwise the basic reproductive number (R0) would be much lower than unity.
For the 12 month outcome the model predictions for the Ifakara and Lambaréné datasets are substantially lower than that observed whereas the model predicted a higher efficacy for the Korogwe site.
Citrate-containing dialysis fluids have shown promising results in terms of improving efficacy and treatment tolerance albeit the citrate concentrations employed in RCA haemodialysis are substantially higher than those of citrate-containing fluids [ 12, 13].
For example, six RCTs (published since 2002) that have assessed the efficacy of knee arthroscopy in the treatment of osteoarthritis [ 16] are probably of substantially higher quality than most shoulder arthroscopy RCTs.
Costs are substantially higher today.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com