Sentence examples for substantially higher dose from inspiring English sources

In view of this, the choice for the experimental procedure seems justified as the present study uses a substantially higher dose.

The opening of the ring at C-7 and C-8 is consistent with the reduction of cytotoxic potency; however, such modulation does not account for the tolerability of substantially higher dose levels than with PTX.

The study of Cao showed that CTG was more potent than dexamethasone (DX) in amelioration of colitis in rats, but it should be noted that CTG was used in a substantially higher dose than DX.

Substantially higher doses of LM975 can be given clinically without dose limiting toxicity.

Patients with a low probability of severe neutropenia (e.g., <30%) as calculated with the nomogram using the standard dose of irinotecan can tolerate substantially higher doses.

For example, during its development, the anti-psychotic drug aripiprazole had no clinical effectiveness at the feasible dose range identified by PET, but in practice, the drug was found to be effective and safe at substantially higher doses.

For instance, AA individuals who carry genetic variants that reduce vitamin D hydroxylation and binding protein stability may require substantially higher doses of vitamin D supplementation to maintain optimal serum 25(OH D levels.

Its main limitations are the substantially higher radiation dose delivered, its reduced accuracy, and that it is relatively expensive [39].

CT exposes the patient to a substantially higher radiation dose than radiography, rendering it unsuitable for the often needed repeated examinations of these patients.

CT exposes the patient to a substantially higher radiation dose than chest radiography, rendering it unsuitable for the often needed repeated examinations of these patients.

This difference could, of course, also arise from the substantially higher carboplatin dose in the CTC regimen.