In summary, PL-MLP was well tolerated and could be administered at substantially higher individual and cumulative doses as compared to free MMC.
The Mov-Avg Cusum method detects a pandemic when the cumulative number of current ILI cases is substantially higher than the expected cumulative number.
The cumulative incidence was also substantially higher after exceeding the 9.00 threshold than after a 190 199 mg/dL 2-h value was reached (2-year risk 0.64 [0.53–0.80]; n = 59).
Our population cumulative incidence estimates (781,867 cases) are substantially higher than the case estimates from various clinical surveillance data [4], [14].
Among long term users, both the median duration of use and cumulative dose within the pregnancy were substantially higher in group 1 (109 days and 4017 mg, respectively) than in the other four groups (46 to 64 days and 832 to 1693 mg, respectively).
Our data showed that the cumulative hazard of cervical precancerous lesions was substantially higher in women aged 25-34 years than in women aged 35 years or older, especially in the HPV screening arm.
Cumulative costs during the study are summarised by treatment arm in Tables 2, 3 and 4. As anticipated, cumulative drug acquisition costs during the study were substantially higher in the irinotecan+5-FU/FA combination treatment arm than the 5-FU/FA treatment arm (£6753 vs £1353, respectively) (Table 2).
However, the higher cumulative costs per patient associated with first line treament with irinotecan+5-FU/FA were offset by substantially lower cumulative costs per patient during the trial and follow-up period, probably attributable to reduced disease progression in the combination treatment arm (39.4% vs 58.3% of patients, respectively) (Douillard et al, 2000).
Costs are substantially higher today.
Or a substantially higher fine for littering.
But we see valuations moving substantially higher.
