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A political fishing expedition through a professor's files would make it substantially harder to conduct research and communicate openly with colleagues.
"Nationwide events like this would be substantially harder to build if you had to pay to get the message to people who care".
However, the solution of an optimization problem using a cost functional (a function of functions of time) is quite different, and substantially harder to solve, than previous optimization problems using cost functions, which depended simply on two variables (such as substrate and enzyme levels in [ 25]).
Participants were faster on average in the single-cue condition (M = 884 ms, SD = 198 ms) than in the three-cue condition (M = 1,166 ms, SD = 295 ms), indicating that, as intended, the three-arrow cue was substantially harder to process than the single-arrow cue.
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It is possible to electrocute enemies in water with the trap bolt from your crossbow, although this is not available until much later in the game and is substantially harder and more costly to perform.
Unfortunately, that enlightened ruling was offset when the court, by a closer, 5-to-4 margin, made it substantially harder for plaintiffs who bring successful lawsuits to enforce civil rights and environmental laws to obtain reimbursement for their legal fees.
This is likely to be a substantially harder and more complex endeavor, however, since the most commonly used approach to addressing post-initiation confounding, generating a "pseudopopulation", usually occurs by weighting, which has not been shown in simulation to produce very predictable confounding amplification.
Sorry, son, I can't help you with that PlayStation VR headset that's got itself somehow wedged somewhere it shouldn't be, daddy's at the end of Kid Icarus and this gigantic-eyed wall-cum-mythical-monster boss is substantially harder than muscle memory is willing to remember.
On the other hand, if a more ambitious climber were to reach the spot first, they might make the route substantially harder by placing bolts farther apart or along a more difficult line.
The same assessment is substantially harder for images of vitrified specimens, where the poor SNR of the images can make it difficult to even see the particle.
These small issues raise concerns that reaching agreement on large politically risky issues will be substantially harder.
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