Total metabolite changes (increases or decreases) were substantially greater for males compared to females in the high dose group.
This is a substantially greater effect than the ∼70-bp decrease caused by tlc1Δ48 in a wild-type background, and it suggests that Rif1 and Rif2 inhibit Ku-mediated telomere lengthening.
Suppression for both patterns decreases as surface slant increases, with substantially greater and steeper changes in suppression for the octotropic plaid.
For instance, in the male cohort described above, the kidneys of double mutant animals showed a 44% decrease in weight relative to controls (Fig. 2F), which is substantially greater than the 26% discrepancy in total body weight.
Responder rates, defined as at least 50%, 75%, or 100% decreases in drop-seizure and total-seizure frequencies with clobazam treatment, were substantially greater than previously published long-term LGS trials, with at least 4 years' longer clobazam treatment data.
Both medications lowered postmeal glucose levels, with numerically greater reductions seen with canagliflozin, as shown by similar decreases in incremental glucose after the meal with both agents; however, canagliflozin provided substantially greater premeal reductions in glucose.
Specifically, the pattern of findings suggest that for those individuals who have a greater sensitivity to reward based on possession of the DRD2 alleleele, decreased frontal-cortical inhibition resulting from possession of a DRD4 VNTR long allele results in substantially greater discounting of delayed rewards.
The cost will be substantially greater".
A college degree still leads to substantially greater lifetime earnings.
"Without that, the challenge would be substantially greater," he added.
