We feel that this new version has substantially gained in clarity and that our conclusions are now even better substantiated.
With the refined biclusters, we next determined whether the gene coexpression is substantially gained or lost in brain diseases compared to normal.
Those with normal weight at baseline who substantially gained weight during the follow-up had an increased risk of 1 month radiating LBP pain assessed at follow-up (table 3).
Intriguingly, during ageing, body weights of dKO and WT mice progressively diverged: whereas ageing WT mice substantially gained weight (64% increase when comparing months 5 and 18), weight gains were attenuated in dKO mice (17, 27, and 35% differences at 12, 15, and 18 months, respectively (P=0.001), Figure 2C left).
However, the use of prior information about the QTL effects can substantially increase genetic gain, and, when the accuracy of the priors is high enough, the responses from MAS are practically as high as those obtained with direct selection on the QTL.
Our results show that genomic selection could substantially increase genetic gains achieved in a purebred pig sire line breeding scheme organized around combined phenotyping of candidates and sibs with pBLUP evaluations, while significantly reducing the annual increase in inbreeding in the population.
What may be less widely appreciated is how the test of time, the strategy of testing and retesting a patient over time, can substantially increase the total gain in certainty that a patient has a particular disease.
But, he added, "growth has slowed substantially; a gain of one-tenth of 1percentt in retail sales is nothing to brag about".
Finally, the presence of transverse steel in strengthened beams resulted in a substantially reduced gain in shear resistance due to CFRP, confirming the existence of an interaction between the transverse steel and the CFRP.
Dekkers [ 1] demonstrated that marker-assisted selection or GS with marker effects derived at the commercial crossbred level can lead to substantially higher gain in CP and a lower rate of inbreeding compared to CCPS when marker effects were estimated accurately.
