No O-labelled product could be seen with AnMan5B until the reaction was allowed to proceed substantially further (up to 24 h incubation), which resulted in detection of small peaks of O-labelled M2 and M3 in the MALDI-TOF MS spectra (data not shown).
Perhaps one valid measure of the value of the ACCE Method, however, should not be whether it derives an estimate that is 100% accurate in theory, but rather whether it, in practice, simply helps to substantially further the goal of achieving nonrandomized study results that more closely approximate randomized trials.
The bill is likely to go substantially further than the previous assault weapons ban, which was passed in 1994 and allowed to lapse 10 years later.
In response to deterioration in the near-term outlook for the economy and intensified strains in financial markets, in recent months the Federal Reserve has eased monetary policy substantially further and taken strong actions to increase market liquidity.
So while the original Human Genome Project provided the sequence of letters that make up the DNA code, ENCODE appeared to have gone substantially further and told us what all these different letters actually do.
The introduction also states the main message of the book: So while the original Human Genome Project provided the sequence of letters that make up the DNA code, ENCODE appeared to have gone substantially further and told us what all these different letters actually do.
Therefore, we are convinced that elucidating similar aspects of biological alterations in animal models and human patients can be a major progress and that translational approaches using appropriate animal models can substantially further our understanding of how organisms respond to stress and the nature of inter-individual differences in the stress response.
Overall, an approach to test specific regions will substantially further our understanding of the process of escape from XCI.
The most northerly record of H. axyridis in Europe is from Trondheim, Norway (Saethre et al., 2010), substantially further north than the Shetland Islands, but Oslo appears to be the most northerly location where H. axyridis has become established.
These companies will either have to cut capex [capital expenditure] substantially further, and by implication future growth, or the dividend – neither option looks particularly good news for shareholders".
