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The authors do cite a recent speech by Mary Miller, under secretary for domestic finance at the Treasury Department, in which she says that too-big-to-fail is substantially fixed by the O.L.A. and other measures.
"Our balance sheet is substantially fixed... our operating profitability has come through quite strongly," he said.
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It is well known that fixed effects estimation substantially exaggerates the attenuation bias when estimated on variables suffering from classical measurement error (Angrist and Krueger 1999).
On the other hand, examining the same regions for mutations that have substantially propagated into human populations (i.e. medium and high frequency SNPs as well as "fixed" recent mutations) demonstrates that these fixed or nearly fixed substitutions are much less prone to G or C → T or A changes.
In addition, protein design methods frequently keep the backbone fixed, an approximation that may substantially limit the ability to accurately model side-chain flexibility.
The fixed links substantially increase the accessibility between the islands and the mainland.
To follow neutrophil and macrophage recruitment over a substantially longer period, we fixed Ras+ larvae and their WT siblings at various time points up to 5 days post-wounding (Fig 2G– J).
We inspect an alternative approach for streamlined design of quantum-dot cellular automata circuits such that the required external fixed inputs are substantially reduced.
In a meta-analysis of 15 quasi-experimental studies of specialized training, caregivers' competence in the classroom improved substantially, particularly when there was fixed curriculum content (Fukkink & Lont, 2007).
The number of fixed SNP varied substantially between breeds: we excluded M MAF < 5% = 13,646 SNP in Duroc, M MAF < 5% = 15,405 SNP in Hampshire, M MAF < 5% = 7,631 SNP in Landrace and, M MAF < 5% = 8,665 SNP in Yorkshire.
After exclusion of this study, the summary odds ratio was homogeneous and substantially elevated (fixed-effects model: 1.43 (95% CI: 0.97, 2.10, heterogeneity: p = 0.212).
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