The clustering procedure is based on our assumption that an error-free barcode is present in substantially more reads than any single erroneous version of the barcode.
Despite a good agreement between the two methods with which hematocrit is determined in clinical routine, the calculated difference of 1.4% will substantially influence transfusion practice, resulting in erroneous RBC transfusion in approximately 21% of our patients.
Even if method 4 gains slightly in precision with an increasing number of cases relative to the number of controls in the second phase, highly unbalanced designs would substantially enforce any bias stemming from erroneous exposure data.
Well, that assumption may be erroneous.
The slight chance for a wrong allocation of multiplexed samples, which may e.g. be due to erroneous bioinformatic sorting of multiplexing tags, will be substantially reduced by the use of two such tags per sample in the NEXTERA protocol [ 49, 50].
We conclude that neither the weak phenotypic manifestation of pathogenic mutations or erroneous description of benign polymorphisms as pathogenic mutations substantially contributes to our data and that instances when an ancestral state matches a human pathogenic mutation can generally be considered to be irreversible states.
In simple terms, high precision values mean that substantially more term-like phrases are selected than the number of erroneous phrases, while high recall values mean that the most term-like phrases are selected from the text.
But if one cannot say, with fair assurance, after pondering all that happened without stripping the erroneous action from the whole, that the judgment was not substantially swayed by the error, it is impossible to conclude that substantial rights were not affected.
However, use of ligand-based approaches can lead to erroneous predictions when structural and dynamic features of the target substantially affect ligand binding.
The removal of erroneous NTP from the active centre upon TL folding contributes substantially to overall transcription fidelity (around an order of magnitude; Table 4), thus being another step assuring accurate transcription.
