Sentence examples for substantially elevated with from inspiring English sources

Among the altered proteins that could potentially mediate this increased host cell interaction is the BON-protein (BCAM0280), which was substantially elevated with time of colonization in both individuals' isolates.

Interestingly, in non-amplified cell lines the SMURF1 shRNA was generally depleted, suggesting a possible additional role in cell growth specific to a non-amplified context, a knockdown threshold effect as speculated above for MYC (endogenous SMURF1 expression levels are substantially elevated with amplification [ 33]), or an off-target effect.

These changes typically reached their maxima between 20 and 40 min after drug intake (Fig. 3), consistent with the rapid absorption and bioavailability of oral diazepam [Moolenaar et al., 1980], after which oscillations reduced to a level still substantially elevated with respect to the baseline, consistent with rapid initial elimination rate, and long half-life [Yamazaki et al., 2007].

With the use of a total cAMP enzyme immunoassay, we found that in MVI-KD myoblasts the level of cAMP was substantially elevated with respect to both untreated (increase by about 40%) and scrambled (increase by about 30%) cells, suggesting a MVI-dependent change in cAMP metabolism.

As important markers to evaluate liver function, the serum levels of AST and ALT in CCl4-induced model group substantially elevated compared with blank control group, while DWYG treatment significantly inhibited the increase in serum levels of ALT and AST induced by CCl4.

The risk of breast cancer is substantially elevated for women with an affected first-degree relative carrying a high-risk mutation in BRCA1 or BRCA2 [ 4- 6] or a mutation in ATM [ 7] or TP53 [ 8- 10], but high-risk mutations in these susceptibility genes are rare and explain only approximately 25% of the familial risk of breast cancer [ 11].

fThe number of hours (h) that the patient had fever before samples were taken Serum concentrations of C-reactive protein (CRP) and serum amyloid A (SAA) were substantially elevated in patients with fever (Table 2 and Additional File 2, Figure S1) which is typical for the syndrome.

Patients with PACG may present with an acute attack, which is associated with severe ocular pain, headaches, and nausea, with substantially elevated intraocular pressure.

They show that variants in DGKK on the X chromosome are associated with substantially elevated risk of this disorder.

And, he emphasized, the new recommendations are for older adults and those with substantially elevated risk of cardiovascular disease.

Therefore, excessive hepatic glucose release probably contributes to postprandial hyperglycemia in individuals with substantially elevated preprandial glucose concentrations.