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Cohort studies with historical controls are also particularly open to bias, as differences between control and intervention periods in patient population, staffing profile, policies and protocols, etc, may well substantially effect patient outcomes, making the intervention appear more effective than it is.
As you may have realized from some of what I've written above, the quality of your speaker set up can have substantially effect the extent to which Atmos sound enhances your gaming experience.
The optical performance of the surgical microscope with the HUD was quantitatively characterized and the addition of the HUD was found not to substantially effect the resolution, field of view, or pincushion distortion of the operating microscope.
The structure of the companion star has been shown to substantially effect the magnitude of removed mass in simulations of Type Ia supernovae (Liu et al. 2012; Meng et al. 2007; Pan et al. 2012).
It claims that there's empirical evidence that its "pro-business" policies work, but it also acknowledges that in many of the states it identifies as top 10 in economic performance "many of the [ pro-business"] policies these states have adopted have not had time to substantially effect (sic) economic performance". Well, what is it, ALEC?
The dominant influence of codon bias over other factors also explains why the use of different cost types in the multivariate regression model does not substantially effect the predictive power.
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A half-dose regimen, although having a reduced delivery cost, inhibits plasmin and fibrinolysis without substantially effecting kallikrein-mediated inflammation associated with bypass surgery.
One view is that SNPs may interact in subtle ways that lead to substantially greater effects than the effect due to any single SNP.
If, however, the decision is viewed as resting on constitutional limitations, it could have a substantially broader effect, he said.
He said: "In combination, such measures could have a substantially greater effect on sugar consumption than in isolation, bringing even greater relief to the over-stretched budgets of the UK's health services".
A comparison of our datasets with published profiles revealed that the differences across protocols and batches had a substantially smaller effect than difference across cell types (Supplementary Figure 2c, d).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com