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Biological effects of cortisol are substantially determined by protein binding of the hormone.
But these are substantially determined by state policy, and that that will influence how people with different levels of education, their health, their behavior, their longevity.
Unfortunately, decades of scientific research have not substantially determined what's likely in the near term (by 2100) even as the long-term picture of inundation remains robust.
Clearly, the robustness of a BLSS subjected to stress will be substantially determined by the robustness of the plant components of the phototrophic unit.
The force applied on ECBG is substantially determined by both the wheel-rail force (external factor) and the transmission rate of track structure (internal factor).
What musicals are is obvious — movies in which people sing and dance — but from the advent of talking pictures, there has been the special genre of the virtual musical, in which there's so much music featured in the course of the action that, even without production numbers or musical performances, the movie feels as substantially determined by the music as any actual musical.
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These institutions substantially determine their own research programs, teaching methods, and means of assessment.
Alcohol is metabolized by an enzyme family that substantially determines peoples' reactions to alcohol.
Might I suggest that the bigger myth is that those who go to Harvard this fall "may substantially determine who runs the country 20 years from now"?
How we live our lives — whether we smoke, exercise, take our medications, and wear seat belts — substantially determines how long we live and the health we enjoy.
Since who goes to Harvard this fall may substantially determine who runs the country 20 years from now, we all, in a sense, have an interest in Harvard's decisions -- and yet it's not an interest we pursue.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com