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Some compounds may increase lifespan simply by substantially depressing fecundity; a substantial depression in fecundity alone is sufficient to increase longevity in Drosophila (Smith 1959).
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However, because the effects of harvest and site preparation are largely transitory, use of these techniques may not substantially depress hare populations if enough stands can be maintained in the 15 40 year age class.
Beyond these analytical problems, W&D's analysis of CMMB for FFSH on Lord Howe Island critically depends on the dubious assumption that rat predation substantially depresses FFSH reproductive success and that eradicating rats would eliminate all egg and chick mortality except that caused by death of a parent (i.e., pf = 1.0).
Purified single-cleaved IgG1 antibodies were shown to have substantially depressed immune effector functions such as ADCC and complement-dependent cytotoxicity [ 18- 20].
There are some data, for example, in rat brain slices, showing that AEA substantially depresses glutamatergic synaptic transmission in the striatum.
Inclusion of feruloylquinic acid, methyl caffeate, or caffeoylquinic acid with normal monolignols considerably depressed lignin formation and substantially improved cell wall hydrolysis and fermentation.
From there things get substantially more depressing.
Carers with better experiences of end-of-life care, including higher levels of mastery and more positive perceptions of care, have been found to be substantially less depressed over time and have better bereavement outcomes [ 9, 10].
This fits with previous findings that some caregivers use positive interpretation as a meaning based coping resource [ 17], and that those with better experiences of end-of-life care, including higher levels of mastery and more positive perceptions of care, have been found to be substantially less depressed over time and have better bereavement outcomes [ 9, 10].
Fitness was however substantially, and similarly, depressed by inbreeding in both sexes.
In 30-day-old plants, miR156b premature transcript levels were reduced from 82.2-fold above WT levels in sk156 leaves down to a mean of 7 ± 5.5 fold above WT in the leaves of these complemented lines, with a minimum of 1.4-fold in line 7 and a maximum of 19.6-fold in line 9. Thus, miR156b transcription was depressed substantially such that ~50% of the complemented lines had WT levels.
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