Sentence examples for substantially deleterious from inspiring English sources

For substantially deleterious mutations (NΔ F ≲ - 1), substitutions are exponentially suppressed.

A central belief underlying the new enthusiasm for gestational chemotherapy is that delay of adjuvant cancer treatment is substantially deleterious to maternal outcomes.

However, even a substantially deleterious mutation has a chance to segregate in the population, especially if the mutation is recessive [ 5].

In sharp contrast, the fitness values reported for mutations affecting RSV U5-IR [ 30], also expressed in the same numerical scale, are substantially more deleterious (−87 % for paired and −55%% for unpaired sites) than the above across-virus species average of −10%%.

The clinically silent onset and the lack of an effective therapy for advanced stage tumours contribute substantially to the deleterious 5-year survival rate of less than 5% (Mimeault et al, 2005).

Children of low socioeconomic status (SES) [ 2, 3], racial and ethnic minorities [ 4, 5], and residents of disadvantaged neighborhoods [ 6, 7] have substantially increased risk for deleterious health outcomes.

The signal for deleterious mutations was substantially reduced if TP53 was excluded (34.9 % of deleterious and 28.5 % of other non-synonymous mutations had LOH).

For genes with high opportunities for slightly deleterious substitution, recombination substantially reduces the rate of molecular evolution, whereas divergence in genes with little opportunity for slightly deleterious substitution is not strongly affected by recombination.

Because we used a strain that produced roughly one mutation per cell cycle, we predicted that neutral or slightly deleterious mutations would substantially outnumber the mutations that made cells grow faster in low sucrose concentrations.

The frequencies of the fixed mutation rates varied only slightly and the optimum mutation rate held constant when β was varied, although the mean effects of deleterious mutations changed substantially.

This is because regulatory elements apparently contribute substantially to both adaptive substitutions and deleterious polymorphisms, with key implications for human evolution and disease [ 69].