Sentence examples for substantially defective from inspiring English sources

In conclusion, although NO plays a major role in mediating coronary arterial dilation under healthy condition, it is substantially defective in coronary arterial disease, yet the poor correlation with DM and dyslipidemia (diseases primarily characterized by endothelial dysfunction) would point to impaired NO function rather than just defective production.

Mutation rates increase substantially in cells defective in DNA mismatch repair or in homologous recombinational repair (HRR).

Collectively, these results demonstrate that NSCs require Bmi-1 for survival and normal proliferation, and that down-regulation of Bmi-1 substantially contributes to the defective proliferation of Atm-/ NSCs.

Although depletion of prohibitin compromises survival of wild-type animals, it substantially extends the lifespan of mutants defective in diapause signaling.

The presence of oxygen vacancy was found to introduce additional adsorption sites, and CO2 adsorption on defective TiO2(101) surface can be substantially modified by the presence of the cuboctahedral Au13 cluster.

The results further suggest that sequence defined antibodies with specificities thoroughly controlled by flow cytometry and genetic antigen-defective mutants or knockouts can substantially reduce the risk of misleading, false-positive results in whole mount imaging and other assays, and thus can improve the scientific value of such assays.

We found that Nef was expressed prior to Vpu and that defective vpu genes were associated with substantially higher levels of NF-κB activation.

Yu et al. [ 31] have shown that in an RDR defective mutant viral RNA turnover is substantially decreased compared to the wild-type.

HAAF is maladaptive in that both defective glucose counterregulation and hypoglycemia unawareness substantially increase the risk of severe clinical hypoglycemia with its morbidity and potential mortality (2, 3).

On the other hand, HAAF is clearly maladaptive since defective glucose counterregulation and hypoglycemia unawareness substantially increase the risk of severe hypoglycemia with its morbidity and potential mortality (26).

Targeted inhibition of ZNF143 substantially increased cellular sensitivity to cisplatin in respiration-defective Tet/on cells.