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H2O2 treatment is known to cause cell death via apoptosis [19, 20] and our results showed that PTE pre-treatment substantially attenuated the H2O2 induced apoptosis in dIMR32 cells in a dose-dependent manner (from 8 μg/ml to 250 μg/ml) except at the concentration of 125 μg/ml (Fig. 4a & b).
Moreover, these neuroimaging markers substantially attenuated the associations between higher and variable SBP with cognitive function.
Combined treatment prevented a sepsis-induced increase in plasma 8-isoprostane and substantially attenuated the gradual increase in TNF-α.
Adjustment for BMI and waist circumference (model 2) substantially attenuated the differences in HDL cholesterol, systolic blood pressure, CRP, and adiponectin between the two groups.
Adjustment for stones substantially attenuated the association between metabolic syndrome and biliary tract cancer (data not shown), suggesting that stones may mediate part of the association between metabolic syndrome and cancer.
Our study shows that adjustment for potential confounders substantially attenuated the association between male gender and hospital death (crude odds ratio 1.21, 95% CI 1.18 1.24 versus adjusted odds ratio 1.05, 95% CI 1.03 1.07).
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Conversely, reducing and/or breaking up sitting time at work may potentially substantially attenuate the risk of metabolic and cardiovascular disease amongst the working [ 3, 10].
In the eastern region, adjustment for SES and COPD SMR substantially attenuates the association from 15.5% down to 6.8% per 10 μg/m increase.
Leptin inhibits ghrelin-induced feeding activity, and ghrelin substantially attenuates the anorexic effect of leptin, thus forming a pair of Yin-Yang partnership in feeding regulation [ 92– 92].
However, adjustment for magnesium intake did not substantially attenuate the inverse association (4, 5), suggesting that other bioactive compounds in coffee may also be responsible.
In both cases, adjustment for hypothesised confounders did not substantially attenuate the relationship when compared with unadjusted or age adjusted models.
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Justyna Jupowicz-Kozak
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