If a complete network connecting the two sites is required, one would not have expected the single mutations to enhance the coupling in TtPFK as substantially as was observed.
Treatment with the dopamine agonist (DA) cabergoline was initiated and over a 10-month period, the macroadenoma shrank substantially to < 1cm (as observed by magnetic resonance imaging).
We also show genetically that reducing DSB level scan, in turn, significantly alleviate the replication block caused by DSBs; cdc6-mn cells containing hypomorphic alleles of SPO11 exhibited substantially rescued DNA replication as observed by FACS and CGH analysis (data not shown).
The presence of multilamellar liposomes in the proteoliposome preparation can substantially diminish the ATPase activity, as observed here for OTG-mediated reconstitutions (Fig. S4), and could partially explain the large variability of reconstitution previously reported for different ABC transporters.
Helices 4 and 5 become substantially more ordered when homodimerized, as observed through comparison of nucleotide-free and GDP bound crystal structures (Low and Löwe, 2006).
The contribution of individuals surviving the winter period to the next season's population may substantially differ, both among different localities (as observed by us) and among years within the same locality [ 19].
In human epidemiology it is well known that transmission may indeed change substantially among social groups and age classes, as observed, for instance, in the early phases of HIV epidemics [1], [2].
The Alb/58 virus showed dual binding to both α2,6 and α2,3 glycan receptors with its α2,6-binding affinity substantially higher than its α2,3-binding affinity (as observed in dose-dependent direct glycan array binding assay).
GSSG cytotoxicity is substantially enhanced under conditions of compromised cellular GSH levels as observed during a wide variety of disease conditions as well as aging (59, 60).
Thus, its dysregulation can substantially affect hepatic and systemic bile acid levels, as observed in the PERDKO mice.
