This diminished response was not due to defective induction of type I IFN, as IFNα levels in the serum of these mice were not substantially altered compared to WT mice.
Furthermore, to concentrate on substantially altered sites and to reduce the statistical complexities associated with large numbers of tests being performed on a small sample set, CpG loci that were considered to be non-variant (β values <0.1 or >0.9 in all samples) were eliminated from the analyses.
But when I went to post my piece the next morning, I clicked on the link to Dyson's essay and discovered it had been substantially altered ― "updated to reflect news developments," as the Times website put it.
This led to a substantially altered ratio of Firmicutes to Bacteroidetes, a ratio that has been used as a diagnostic parameter in studies of disease (see sidebar).
The intracellular redox state was substantially altered after exposure to UVA but not UVB, but such differences in the redox state did not seem to affect the transactivation of NF-κB in our system, which has been suggested of others.
Since the lower-termite gut environment is centrally important to nutrition, physiology and symbiotic relationships with protists and bacteria, we hypothesized that gene expression in this environment is substantially altered in response to caste-regulatory factors and caste composition.
Synthesis of BiNPs at 80 °C in the presence of small molecules with carbonyl groups, such as dihydroxyacetone, ribose (an aldopentose), fructose (a ketohexose), or maltose (a reducing disaccharide), all enabled the formation of BiNPs, albeit with substantially altered morphology relative to the glucose-coated BiNPs.
These results imply that gas well deliverability may increase substantially when wettability is altered to intermediate gas-wetting.
Unlike other Cretan artists who had moved to Venice, El Greco substantially altered his style and sought to distinguish himself by inventing new and unusual interpretations of traditional religious subject matter.
Yet despite significant policy shifts, the long-term social inequalities that many language education policies were designed to address have yet to be substantially altered in the region, in part due to the significant lag in implementation of these measures.
