These later waves of immigration substantially altered the formerly homogeneous character of the population.
Buckley v. Valeo substantially altered the campaign finance landscape envisaged by Congress.
It was shown that the extent of substrate deformation substantially altered the behaviour displayed during bonding of the particles.
A timely tackle or a favorable bounce for the Oakland Raiders 10 months ago could have substantially altered the billing for today's game at Giants Stadium.
Bach may also have substantially altered the music in his adaptation, but only the most foolhardy musical necromancer would try to channel those impulses.
"To establish the proposition that railroads substantially altered the course of economic growth," Fogel wrote, "one must do more than provide information on the services of railroads.
Changing the plasmid design, from a cytomegalovirus (CMV) to an ubiquitin C (UbC) promoter substantially altered the duration of expression.
Industry, urban development, and other anthropogenic influences have substantially altered the composition and size-distribution of atmospheric aerosol particles over the last century.
If the filmmakers can show how they substantially altered the storyline from the Ellison original, they're probably off the hook — legally, at least.
Although newer antifungal drugs have substantially altered the natural history of invasive aspergillosis, the disease still accounts for significant morbidity and mortality in hematopoietic stem cell transplant recipients.
Mobile elements such as Alu repeats have substantially altered the architecture of the human genome, and de novo mobile element insertions sometimes cause genetic disorders.
