The sentencing starting point for a murder committed by a child was 12 years' detention, Haddon-Cave said, but their case was "substantially aggravated" by the fact that it was a double murder, that their victims were asleep and must have "suffered terribly" in the moments before their deaths.
Lack of PD-1 substantially aggravated the pathological phenotype of the PLPtg mutants compared to genuine PLPtg mutants, whereas the PD-1 deletion alone did not cause alterations in the CNS.
This is re-confirmed by our finding that smoking substantially aggravated TB mortality risks among those with TB history (from HR = 4.75 to HR = 10.10).
Such small ischemic lesions ("silent stroke", cortical microinfarcts; Kovari et al., 2007), which in isolation would not alter cognition, substantially aggravate dementia, indicating that cerebral ischemia may interact with AD pathology.
In our current meta-analyses, frequency of ferritin deficiency increased by twofold in patients at 6 months after surgery, and this trend became substantially aggravated at 24 and 36 months.
This may be related to the relative stability of the glucokinase-related β-cell defect, as insulin secretion in MODY2 subjects does not seem to aggravate substantially over time.
He found that the laws led to "substantially higher rates" of aggravated assault, rape, robbery, and murder.
Patients can be compensated only if designated physicians certify that toxic materials or other hazards at ground zero were "substantially likely" to have aggravated or caused the cancer.
"I believe it aggravates the problem substantially," he said.
The large numbers of migrants surging into urban areas have substantially increased urban population density, aggravated the burden of infectious diseases and facilitated their transmission [ 14].
