The existing office building stock is a key target for energy retrofits to substantially reduce adverse impacts on the environment, human health, and the economy.
We determine whether concurrent physical frailty and cognitive impairment, compared with physical frailty alone substantially increased adverse health outcomes (functional disability, hospitalization, poor quality of life [QOL], and mortality).
Chronic Kidney disease (CKD) has emerged as a major public health epidemic, which contributes substantially to adverse clinical and economic outcomes [ 1– 4].
However, our studies were in four urban centers where antenatal clients received good primary care and malaria was not contributing substantially to adverse outcomes.
The lower doses of toceranib used in this study were associated with a substantially reduced adverse event profile compared to the established label dose of 3.25 mg/kg EOD.
Using Printex90 and ultrafine metallic particles (cobalt, nickel, and titanium), Dick et al. showed that surface reactivity in particular, the existence of reactive compounds on a particle surface can substantially modify adverse effects (Dick et al. 2003).
During long-term follow-up, as compared with the first year, there were substantially fewer adverse events (Supplementary Table 2), with fewer subject reports in both groups; most were mild, grade 1 and 2, with none being grade 4. Infections were slightly more common in the rituximab group, but this difference was not significant.
This study and virtually all previous reports have also shown that schizophrenia itself has substantially more adverse effects on male than female reproduction; this disorder is also more deleterious in its effects on cognitive abilities among males than females (e.g., Abu-Akel and Bo 2013).
45– 48 Long-term maintenance therapy with lactulose to prevent recurrence of overt episodes appears to be effective, but patient compliance may be substantially hindered by adverse events (eg, diarrhea, flatulence).
