Sentence examples for substantially abrogated from inspiring English sources

Accordingly, G2-arrest, and cellular senescence largely dependent on p21 were substantially abrogated.

Knockout of Nrf2 in mice substantially abrogated the inducible expression of ARE-mediated detoxifying and antioxidant enzymes, and rendered these mice highly susceptible to carcinogens and/or oxidative damages [13], [14].

More importantly, the cell death was substantially abrogated in the presence of 3-MA.

In addition, TNT003 substantially abrogated complement deposition induced by AMR-associated DSA from these 10 cardiac transplant patients.

On the other hand, the expression of DBC1 was not substantially abrogated in cancers from any source.

Out data show that sulindac sulfide substantially abrogated the cellular organization of F-actin (Z-section) on fibronectin in MDA-MB231 and HCC38 TNBC cells.

As shown in Figures 6c and e, MDL substantially abrogates cimes-induced upregulation of CDK5 and p25, suggesting their involvement in signaling downstream of calpain.

In an overview of studies of the roles played by B cells and B cell depletion in RA, Tsokos [ 1] suggested that B cells contribute to the expression of autoimmunity, and that antibodies that target B cells, such as anti-CD20, may substantially abrogate expression of disease.

Release of the chemokines MIP1-β and RANTES, which rank highly in the hierarchy of effector functions (Fig. 1B), remained similar in magnitude to the levels secreted in response to wild-type (WT) or 'index' peptide when clone 003 CTL were stimulated with the 3H variant, whereas secretion of lower-order cytokines was substantially reduced or abrogated (Fig. 1C).

In MCF-7CLU cells the changes in ERalpha expression are substantially reduced but not completely abrogated.

On the protein level, Sorafenib concentrations ≥10  μM completely abrogated cyclin D1 and substantially reduced the expression of cyclins E1 and A2, respectively.