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Deleting 60 amino acids from the TOG1-TOG2 linker substantially abolished rescue activity.
Accordingly, p44/42 MAPK activation induced by Cd was substantially abolished in the presence of AG1478.
This cytokine withdrawal apoptosis in Treg cells is substantially abolished by the γc cytokines in vitro.
In control mice, ghrelin immunoreactivity was mainly detected in the cytoplasm of LCs, which was substantially abolished by IR.
(B ) Stu2p function is substantially abolished when the TOG1-TOG2 lisker is truncated by 60 amino acids.
When the wild-type 16 nt probe was replaced with a mutated oligonucleotide, the binding activity of the protein complex was substantially abolished (Fig. 2C).
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As depicted in Figure 9 Aplidin was able to substantially abolish VEGF secretion in the medium at 6 and 24 h after drug-washout.
The alternative minimum tax remains in effect even though there seems to be bipartisan agreement that it is an abomination, and despite repeated recommendations that it be abolished or substantially reformed.
For AVFluIgG03, mutations at E126D, S129L and N155S abolished or substantially reduced binding of the AVFluIgG03 to the rHA antigen.
However, expression of the genes for cereolysin O (clo), phosphatidylcholine specific phospholipase C (plcB) and a serine protease (sfp) (Table S3) was comparable to B. anthracis and either completely abolished or substantially weaker compared to the B. cereus DSM 31 control strain.
The enzyme's activity is substantially impaired, but not abolished, without divalent metal ions relative to its performance with Mg2+ and Ca2+.
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